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Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

ABSTRACT: Pair-wise comparison between: BAT-gal positive b-catenin accumulating cluster cells (Hesx1Cre/+;Ctnnb1+/lox(ex3);BAT-gal) with BAT-gal negative b-catenin non-accumulating (normal) cells (Hesx1Cre/+;Ctnnb1+/lox(ex3);BAT-gal) from a pretumoral 18.5dpc mouse pituitary.

ORGANISM(S): Mus musculus

SUBMITTER: Cynthia Andoniadou

PROVIDER: E-MEXP-3492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.

Andoniadou Cynthia L CL Gaston-Massuet Carles C Reddy Rukmini R Schneider Ralph P RP Blasco Maria A MA Le Tissier Paul P Jacques Thomas S TS Pevny Larysa H LH Dattani Mehul T MT Martinez-Barbera Juan Pedro JP

Acta neuropathologica 20120218 2

Activating mutations in the gene encoding β-catenin have been identified in the paediatric form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), a histologically benign but aggressive pituitary tumour accounting for up to 10% of paediatric intracranial tumours. Recently, we generated an ACP mouse model and revealed that, as in human ACP, nucleocytoplasmic accumulation of β-catenin (β-cat(nc)) and over-activation of the Wnt/β-catenin pathway occurs only in a very small propor ...[more]

PMID: 22349813

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