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Neuroblastoma Disease Pathogenesis is Modulated By Epigenetically Regulated MicroRNAs - Gene expression data

ABSTRACT: The data represents gene expression data from 42 primary neuroblastoma tumors using Affymetrix exon arrays. Data on an accompanying MeDIP experiment on tiling arrays is also available from ArrayExpress (see E-MEXP-3498).

ORGANISM(S): Homo sapiens

SUBMITTER: Sudipto Das

PROVIDER: E-MEXP-3517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs.

Das S S Bryan K K Buckley P G PG Piskareva O O Bray I M IM Foley N N Ryan J J Lynch J J Creevey L L Fay J J Prenter S S Koster J J van Sluis P P Versteeg R R Eggert A A Schulte J H JH Schramm A A Mestdagh P P Vandesompele J J Speleman F F Stallings R L RL

Oncogene 20120716 24

MicroRNAs (miRNAs) contribute to the pathogenesis of many forms of cancer, including the pediatric cancer neuroblastoma, but the underlying mechanisms leading to altered miRNA expression are often unknown. Here, a novel integrated approach for analyzing DNA methylation coupled with miRNA and mRNA expression data sets identified 67 epigenetically regulated miRNA in neuroblastoma. A large proportion (42%) of these miRNAs was associated with poor patient survival when underexpressed in tumors. More ...[more]

PMID: 22797059

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