Unknown,Transcriptomics,Genomics,Proteomics

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Kras mutant v WT with or without AZD6244 in vivo study

ABSTRACT: HCT116 (kRas mt) cells and HKH2 (Kras wt) cells were implanted into the right and left flanks of nude mice and either untreated or treated with a MEK inhibitor (AZD6244) over time. Tumours were excised and harvested for RNA extraction at the end of the experiment and hybridised to the Colorectal DSA.

ORGANISM(S): Homo sapiens

SUBMITTER: wendy allen 

PROVIDER: E-MEXP-3557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.

Guinney Justin J   Ferté Charles C   Dry Jonathan J   McEwen Robert R   Manceau Gilles G   Kao K J KJ   Chang Kai-Ming KM   Bendtsen Claus C   Hudson Kevin K   Huang Erich E   Dougherty Brian B   Ducreux Michel M   Soria Jean-Charles JC   Friend Stephen S   Derry Jonathan J   Laurent-Puig Pierre P  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131029 1

<h4>Purpose</h4>KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGF receptor (EGFR) monoclonal antibodies in colorectal cancer, motivating efforts to identify novel molecular aberrations driving RAS. This study aimed to build a quantitative readout of RAS pathway activity to (i) uncover molecular surrogates of RAS activity specific to colorectal cancer, (ii) improve the prediction of cetuximab response in patients, and (iii) suggest new treatment strategies.<h4>Experimenta  ...[more]

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