Homeodomain dependent gene expression in HOX transformed primary cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Slany
PROVIDER: E-MEXP-3617 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The homeodomain region controls the phenotype of HOX-induced murine leukemia.
Breitinger Constanze C Maethner Emanuel E Garcia-Cuellar Maria-Paz MP Slany Robert K RK
Blood 20120918 19
HOX proteins are widely involved in hematopoietic development. These transcription factors combine a conserved DNA-binding homeobox with a divergent N-terminus that mediates interaction with variable cofactors. The resulting combinatorial diversity is thought to be responsible for mammalian HOX specificity. Contrasting this proposed mechanism for normal HOX function, here we demonstrate that, in the context of hematopoietic immortalization and leukemogenesis, individual HOX properties are govern ...[more]
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