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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparing the transcriptome in cumulus and granulosa cells

ABSTRACT: Comparing cumulus and granulosa cells from human individual pre-ovulatory follicles after controlled ovarian stimulation

ORGANISM(S): Homo sapiens

SUBMITTER: Marie Louise Grøndahl

PROVIDER: E-MEXP-3641 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Specific genes are selectively expressed between cumulus and granulosa cells from individual human pre-ovulatory follicles.

Grøndahl M L ML Andersen C Yding CY Bogstad J J Borgbo T T Boujida V Hartvig VH Borup R R

Molecular human reproduction 20120824 12

During folliculogenesis, the granulosa cells differentiate into two cell types: cumulus cells (CCs) and mural granulosa cells (MGCs). The objective of the study was to generate and compare the transcriptomes of MGCs and CCs from the pre-ovulatory follicle to characterize the detailed profile of the two cell populations shortly before ovulation. Twenty-one IVF/ICSI patients undergoing controlled ovarian stimulation (COS) donated CCs and MGCs from individual follicles containing metaphase II oocyt ...[more]

PMID: 22923488

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