Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Heike Laman
PROVIDER: E-MEXP-369 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Laman Heike H Funes Juan M JM Ye Hongtao H Henderson Stephen S Galinanes-Garcia Laura L Hara Eiji E Knowles Phillip P McDonald Neil N Boshoff Chris C
The EMBO journal 20050811 17
D cyclins (D1, D2 and D3) and their catalytic subunits (cyclin-dependent kinases cdk4 and cdk6) have a facilitating, but nonessential, role in cell cycle entry. Tissue-specific functions for D-type cyclins and cdks have been reported; however, the biochemical properties of these kinases are indistinguishable. We report that an F box protein, Fbxo7, interacted with cellular and viral D cyclins and distinguished among the cdks that bind D-type cyclins, specifically binding cdk6, in vitro and in vi ...[more]