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Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice

ABSTRACT: Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of tBHQ or arsenic treatment given alone.

ORGANISM(S): Mus musculus

SUBMITTER: Alvaro Puga

PROVIDER: E-MEXP-371 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

Kann Simone S Estes Cameron C Reichard John F JF Huang Ming-Ya MY Sartor Maureen A MA Schwemberger Sandy S Chen Ying Y Dalton Timothy P TP Shertzer Howard G HG Xia Ying Y Puga Alvaro A

Toxicological sciences : an official journal of the Society of Toxicology 20050713 2

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate, and bladder cancer. Arsenic is also a cardiovascular and a central nervous system toxicant, and it has genotoxic and immunotoxic effects. Paradoxically, arsenic trioxide is used successfully in the treatment of acute promyelocytic leukemia and multiple myeloma. Arsenic induces oxidative stress, and its toxicity is decreased by free thiols and increased by glutathione depleti ...[more]

PMID: 16014739

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