Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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BMT_aGvHD_Intestine


ABSTRACT: Mice received TBI and allogeneic bone marrow transplantation. One group without and one group with T cells. On day 14 after transplantation mice were sacrificed and the intestinal tract was isolated. RNA was isolated from the intestinal tract of the two experimental groups.

ORGANISM(S): Mus musculus

SUBMITTER: Dietmar Pfeifer 

PROVIDER: E-MEXP-3807 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Acute graft-versus-host disease (GvHD) is a complex process involving endothelial damage and neovascularization. Better understanding of the pathophysiology of neovascularization during GvHD could help to target this process while leaving T-cell function intact. Under ischemic conditions, neovascularization is regulated by different micro RNAs (miRs), which potentially play a role in inflamed hypoxic GvHD target organs. We observed strong neovascularization in the murine inflamed intestinal trac  ...[more]

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