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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mycobacterial TDM Reprograms Macrophage Global Gene Expression

ABSTRACT: Effect of mycobacterial cell wall component TDM (trehalose dimycolate) of murine macrophage gene expression.

ORGANISM(S): Mus musculus

SUBMITTER: Kyle Rohde

PROVIDER: E-MEXP-3814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.

Sakamoto Kaori K Kim Mi Jeong MJ Rhoades Elizabeth R ER Allavena Rachel E RE Ehrt Sabine S Wainwright Helen C HC Russell David G DG Rohde Kyle H KH

Infection and immunity 20121221 3

Trehalose 6,6'-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role of TDM in the innate immune response to Mycobacterium tuberculosis, microarray analysis was used to examine gene regulation in murine bone marrow-derived macrophages in response to 90-μm-diameter polystyrene microspheres coated with TDM. A large number of genes, particularly those involved in the immune response and macrophage function, were up- or downregulated ...[more]

PMID: 23264051

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