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Transcription profiling of endothelial cells and dermal fibroblasts treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype

ABSTRACT: Both human endothelial cells and dermal fibroblasts have been treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype.

ORGANISM(S): Homo sapiens

SUBMITTER: Marzia Dolcino

PROVIDER: E-MEXP-382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach.

Lunardi Claudio C Dolcino Marzia M Peterlana Dimitri D Bason Caterina C Navone Riccardo R Tamassia Nicola N Beri Ruggero R Corrocher Roberto R Puccetti Antonio A

PLoS medicine 20051206 1

<h4>Background</h4>Systemic sclerosis is an autoimmune disease characterized by immunological abnormalities, vascular damage, and fibroblast proliferation. We have previously shown that a molecular mimicry mechanism links antibodies against the human-cytomegalovirus-derived protein UL94 to the pathogenesis of systemic sclerosis. The UL94 epitope shows homology with NAG-2, a surface molecule highly expressed on endothelial cells. Anti-UL94 peptide antibodies purified from patients' sera induce ap ...[more]

PMID: 16318412

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The fish pathogen Aliivibrio salmonicida LFI1238 can degrade and utilize chitin as a nutrient source despite major gene loss in the chitinolytic pathway

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