Dataset Information
Transcription profiling following expression of the transcription factor Hoxa2 in first branchial arch cells
Ontology highlight
ABSTRACT:
To understand the molecular control of inter-branchial arch identity, we forced expression of the transcription factor Hoxa2 (the main determinant of second branchial arch fate) in first branchial arch mice cells, and analyzed changes in global expression.
ORGANISM(S): Mus musculus
SUBMITTER: Leo Zeef
PROVIDER: E-MEXP-3837 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.
PloS one 20130509 5
Branchial arches are externally visible tissue bands in the head region of all vertebrate embryos. Although initially formed from similar components, each arch will give rise to different head and neck structures. In a screen designed to characterize the molecular control of branchial arch identity in mouse, we identified Pcp4 as a second branchial arch-specific molecular signature. We further show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the s ...[more]
