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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation

ABSTRACT: Many organisms in the nature can drive themselves into an ametabolic state known as anhydrobiosis upon extreme desiccation. The nematode C. elegans is one of them. However, the anhydrobiotic ability of the worm is limited to a special developmental stage known as the dauer. Besides, the dauer larvae must be first treated by a mild desiccation stress (preconditioning) so that they gain desiccation tolerance. In this study, we investigated the differential gene expression during preconditioning in the C. elegans dauer.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Cihan Erkut

PROVIDER: E-MEXP-3899 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation.

Erkut Cihan C Vasilj Andrej A Boland Sebastian S Habermann Bianca B Shevchenko Andrej A Kurzchalia Teymuras V TV

PloS one 20131204 12

Massive water loss is a serious challenge for terrestrial animals, which usually has fatal consequences. However, some organisms have developed means to survive this stress by entering an ametabolic state called anhydrobiosis. The molecular and cellular mechanisms underlying this phenomenon are poorly understood. We recently showed that Caenorhabditis elegans dauer larva, an arrested stage specialized for survival in adverse conditions, is resistant to severe desiccation. However, this requires ...[more]

PMID: 24324795

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