Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MS_MSC

ABSTRACT: Transcriptional profile of bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients, before and after autologous hematopoietic stem cell transplantation, and compare to healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Eduardo Donadi 

PROVIDER: E-MEXP-3905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts.

de Oliveira Gislane L V GL   de Lima Kalil W A KW   Colombini Amanda M AM   Pinheiro Daniel G DG   Panepucci Rodrigo A RA   Palma Patrícia V B PV   Brum Doralina G DG   Covas Dimas T DT   Simões Belinda P BP   de Oliveira Maria C MC   Donadi Eduardo A EA   Malmegrim Kelen C R KC  

Cell transplantation 20131120 2

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system, due to an immune reaction against myelin proteins. Multipotent mesenchymal stromal cells (MSCs) present immunosuppressive effects and have been used for the treatment of autoimmune diseases. In our study, gene expression profile and in vitro immunomodulatory function tests were used to compare bone marrow-derived MSCs obtained from MS patients, at pre- and postautologous hematopoietic stem cell tr  ...[more]

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