Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Amy Samuels
PROVIDER: E-MEXP-3916 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood cancer journal 20140801
Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. This study was designed to establish a preclinical model of resistance to induction therapy in childhood T-ALL to examine the emergence of drug resistance and identify novel therapies. Patient-derived T-ALL xenografts in immune-deficient (non-obese diabetic/severe combined immunodeficient) mice were exposed to a four-drug combination of vincristine, dexamethasone (DEX), L-a ...[more]