Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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A Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia


ABSTRACT: The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. This study was designed to establish a preclinical model of resistance to induction therapy in childhood T-ALL to examine the emergence of drug resistance and identify novel therapies. We performed transcription profiling by array of human CD45-positive human lymphocytes from patients with acute pediatric lymphoblastic leukemia, and from xenografted NOD/SCID mice treated with vincristine, daunorubicin, dexamethasone and L-asparagine. Several different treatment regimes were used in this study (VLXD, VLXDR, VLXD2, VXL and VLXD2-ALL31) and are summarised in the protocols associated with this submission.

ORGANISM(S): Homo sapiens

SUBMITTER: Amy Samuels 

PROVIDER: E-MEXP-3916 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia.

Samuels A L AL   Beesley A H AH   Yadav B D BD   Papa R A RA   Sutton R R   Anderson D D   Marshall G M GM   Cole C H CH   Kees U R UR   Lock R B RB  

Blood cancer journal 20140801


Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. This study was designed to establish a preclinical model of resistance to induction therapy in childhood T-ALL to examine the emergence of drug resistance and identify novel therapies. Patient-derived T-ALL xenografts in immune-deficient (non-obese diabetic/severe combined immunodeficient) mice were exposed to a four-drug combination of vincristine, dexamethasone (DEX), L-a  ...[more]

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