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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MiR-155 is protective of dietary non-alcoholic hepatosteatosis

ABSTRACT: We used microarrays to characterize the gene expression changes in liver caused by high fat diet feeding to C57BL/6 WT and miR-155-/- mice. Livers were collected from male mice at 24 weeks of age for RNA extraction and hybridization on Affymetrix mouse gene 1.0 ST array . We extracted RNA from 3 animals/group for microarray analysis (total N = 6 samples)

ORGANISM(S): Mus musculus

SUBMITTER: Ashley Miller

PROVIDER: E-MEXP-3932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice.

Miller Ashley M AM Gilchrist Derek S DS Nijjar Jagtar J Araldi Elisa E Ramirez Cristina M CM Lavery Christopher A CA Fernández-Hernando Carlos C McInnes Iain B IB Kurowska-Stolarska Mariola M

PloS one 20130821 8

Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver. We aimed to investigate the functional role of miR-155 in hepatic steatosis. Male C57BL/6 wild-type (WT) and miR-155(-/-) mice were fed either normal chow or high fat diet (HFD) for 6 months then lipid levels, metabolic and inflammatory parameters were assessed in liver ...[more]

PMID: 23991091

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