Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: William Davies
PROVIDER: E-MEXP-3943 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Trent Simon S Fry Jonathan P JP Ojarikre Obah A OA Davies William W
Molecular autism 20140306 1
<h4>Background</h4>The 39,XY*O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurobiology underlying these phenotypes is unclear, although there is evidence for serotonergic abnormalities in the striatum and hippocampus.<h4>Methods</h4>Using microarray and quantitative gene expression analyses, and gas chromatography-mass sp ...[more]