Ontology highlight
ABSTRACT:
INSTRUMENT(S): G2565BA Microarray Scanner
ORGANISM(S): Mus musculus
SUBMITTER: Joakim Lunderberg
PROVIDER: E-MEXP-431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
BMC genomics 20060406
<h4>Background</h4>Expression of the LIM-homeobox gene Lhx2 in murine hematopoietic cells allows for the generation of hematopoietic stem cell (HSC)-like cell lines. To address the molecular basis of Lhx2 function, we generated HSC-like cell lines where Lhx2 expression is regulated by a tet-on system and hence dependent on the presence of doxycyclin (dox). These cell lines efficiently down-regulate Lhx2 expression upon dox withdrawal leading to a rapid differentiation into various myeloid cell t ...[more]