Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of liver-specific transcription in Mtf1 conditional knockout mice and control littermates to identify MTF-1 target genes and cadmium-inducible genes in the adult liver

ABSTRACT: A search for MTF-1 target genes and cadmium-inducible genes in the adult liver was performed by comparing liver-specific transcription in Mtf1 conditional knockout mice and control littermates.

ORGANISM(S): Mus musculus

SUBMITTER: Walter Schaffner

PROVIDER: E-MEXP-438 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione.

Wimmer Ursula U Wang Ying Y Georgiev Oleg O Schaffner Walter W

Nucleic acids research 20051012 18

Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1 in the liver after birth is no longer lethal. For this study, Mtf1 conditional knockout mice and control littermates were both mock- or cadmium-t ...[more]

PMID: 16221973

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Dataset Information

Transcription profiling of liver-specific transcription in Mtf1 conditional knockout mice and control littermates to identify MTF-1 target genes and cadmium-inducible genes in the adult liver

Publications

Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione.

Similar Datasets

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