Nef Gene expression during sex determination
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Olivier Schaad
PROVIDER: E-MEXP-454 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.
Nef Serge S Schaad Olivier O Stallings Nancy R NR Cederroth Christopher R CR Pitetti Jean-Luc JL Schaer Guillaume G Malki Safia S Dubois-Dauphin Michel M Boizet-Bonhoure Brigitte B Descombes Patrick P Parker Keith L KL Vassalli Jean-Dominique JD
Developmental biology 20051007 2
The primary event in mammalian sexual development is the differentiation of the bipotential gonads into either testes or ovaries. Our understanding of the molecular pathways specifying gonadal differentiation is still incomplete. To identify the initial molecular changes accompanying gonadal differentiation in mice, we have performed a large-scale transcriptional analysis of XX and XY Sf1-positive gonadal cells during sex determination. In both male and female genital ridges, a robust genetic pr ...[more]
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