Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of C. elegans 12 hours and 24 hours post exposure to fungal pathogen, Drechmeria coniospora

ABSTRACT: Transcriptome study of C.elegans animals 12 hours and 24 hours post exposure to fungal pathogen, Drechmeria coniospora.

INSTRUMENT(S): ScanArray 4000XL [PerkinElmer]

ORGANISM(S): Caenorhabditis elegans

DISEASE(S): infected with Drechmeria coniospora

SUBMITTER: Jonathan Ewbank 

PROVIDER: E-MEXP-479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides.

Pujol Nathalie N   Zugasti Olivier O   Wong Daniel D   Couillault Carole C   Kurz C Léopold CL   Schulenburg Hinrich H   Ewbank Jonathan J JJ  

PLoS pathogens 20080718 7

Encounters with pathogens provoke changes in gene transcription that are an integral part of host innate immune responses. In recent years, studies with invertebrate model organisms have given insights into the origin, function, and evolution of innate immunity. Here, we use genome-wide transcriptome analysis to characterize the consequence of natural fungal infection in Caenorhabditis elegans. We identify several families of genes encoding putative antimicrobial peptides (AMPs) and proteins tha  ...[more]

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