Transcription profiling of primary mouse keratinocytes infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Steffi Herold
PROVIDER: E-MEXP-497 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1.
Gebhardt Anneli A Frye Michaela M Herold Steffi S Benitah Salvador Aznar SA Braun Kristin K Samans Birgit B Watt Fiona M FM Elsässer Hans-Peter HP Eilers Martin M
The Journal of cell biology 20060101 1
Myc plays a key role in homeostasis of the skin. We show that Miz1, which mediates Myc repression of gene expression, is expressed in the epidermal basal layer. A large percentage of genes regulated by the Myc-Miz1 complex in keratinocytes encode proteins involved in cell adhesion, and some, including the alpha6 and beta1 integrins, are directly bound by Myc and Miz1 in vivo. Using a Myc mutant deficient in Miz1 binding (MycV394D), we show that Miz1 is required for the effects of Myc on keratino ...[more]
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