Dataset Information
Transcription profiling of mouse with ablation of connexin 30 in the stria vascularis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Beatrice Regnault
PROVIDER: E-MEXP-558 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
Proceedings of the National Academy of Sciences of the United States of America 20070330 15
The endocochlear potential (EP) is essential to hearing, because it provides approximately half of the driving force for the mechanoelectrical transduction current in auditory hair cells. The EP is produced by the stria vascularis (SV), a vascularized bilayer epithelium of the cochlea lateral wall. The absence of the gap junction protein connexin30 (Cx30) in Cx30(-/-) mice results in the SV failure to produce an EP, which mainly accounts for the severe congenital hearing impairment of these mice ...[more]
