Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000A [Axon Instruments]
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Olivier GADAL
PROVIDER: E-MEXP-651 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Berger Axel B AB Decourty Laurence L Badis Gwenaël G Nehrbass Ulf U Jacquier Alain A Gadal Olivier O
Molecular and cellular biology 20070917 22
Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III, and II is a key requirement for growth control. Using a novel global genetic approach, we showed that the absence of Hmo1 becomes lethal when combined with mutations of components of either the RNA Pol II or Pol I transcription machineries, of specific RP, or of the TOR pathway. Hmo1 directly interacts with bo ...[more]