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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human T lymphocytes from patients with hypogammaglobulinemia of unknown cause (CVID) vs. hypogammaglobulinemia of known cause (XLA) and vs. healthy controls

ABSTRACT: Comparison of gene expression in T lymphocytes from patients with hypogammaglobulinemia of unknown cause (CVID), patients with hypogammaglobulinemia of known cause (XLA) and healthy controls

ORGANISM(S): Homo sapiens

SUBMITTER: P Aukrust

PROVIDER: E-MEXP-76 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells.

Holm A M AM Sivertsen E A EA Tunheim S H SH Haug T T Bjerkeli V V Yndestad A A Aukrust P P Frøland S S SS

Clinical and experimental immunology 20041101 2

Common variable immunodeficiency (CVID) represents a heterogeneous group of antibody deficiency syndromes, characterized by defective antibody production in which T cell deficiency may play a pathogenic role. A subgroup of CVID patients has impaired in vitro T cell proliferation. Using microarray analyses of T cells from these patients, we found a gene expression pattern different from healthy controls and patients with X-linked agammaglobulinaemia. The profile of the differentially expressed ge ...[more]

PMID: 15498038

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