Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of liver from wild type mice of different ages to determine whether gene expression changes in naturally aged mice overlap with those from DNA repair deficient mice


ABSTRACT: To investigate whether and to which extent the gene expression changes in DNA repair deficient mice (i.e. Csbm/m/Xpa-/- and Ercc1-/-) overlap with those observed in a natural aged liver, we sought to compare the full mouse liver transcriptome of adult 16-, 96- and 130-week old wt C57Bl/6J mice (n=4) with that of adult 8-week old wt C57Bl/6J mice

ORGANISM(S): Mus musculus

SUBMITTER: Gijsbertus van der Horst 

PROVIDER: E-MEXP-839 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA lesions and cytotoxic DNA interstrand crosslinks. Mild mutations in XPF cause the cancer-prone syndrome xeroderma pigmentosum. A patient presented with a severe XPF mutation leading to profound crosslink sensitivity and dramatic progeroid symptoms. It is not known how unrepaired DNA damage accelerates ageing or its relevance to natural ageing. Here we show a highly significant correlation between the liver transcriptome of old  ...[more]

Similar Datasets

2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
2006-12-21 | E-MEXP-834 | biostudies-arrayexpress
2007-01-01 | E-MEXP-835 | biostudies-arrayexpress
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
2007-01-01 | E-MEXP-840 | biostudies-arrayexpress
2021-05-15 | E-MTAB-10393 | biostudies-arrayexpress
2021-01-26 | PXD017940 | Pride
2009-04-01 | E-MEXP-1968 | biostudies-arrayexpress
2009-03-01 | E-MEXP-1975 | biostudies-arrayexpress
2019-07-05 | MSV000084062 | MassIVE