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Transcription profiling of wild type and Pdr1 and Pdr3 knock-out yeast treated with detergents DCP (2-4-dichlorophenol) and POELE (polyoxyethylen-9-laurylether)

ABSTRACT: DCP (2-4-dichlorophenol; 0,3mM) and POELE (polyoxyethylen-9-laurylether; 0,1mM)treatment on Saccharomyces cerevisiae W303-1A wild-type cells. Further investigation of the involvement of the transcripton factors Pdr1 and Pdr3 in DCP treated cells. Cells were growing in early exponential phase in rich medium.

INSTRUMENT(S): Axon- GenePix4000B

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Hubert Wolfger 

PROVIDER: E-MEXP-865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Membrane-active compounds activate the transcription factors Pdr1 and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in saccharomyces cerevisiae.

Schüller Christoph C   Mamnun Yasmine M YM   Wolfger Hubert H   Rockwell Nathan N   Thorner Jeremy J   Kuchler Karl K  

Molecular biology of the cell 20070919 12

The Saccharomyces cerevisiae zinc cluster transcription factors Pdr1 and Pdr3 mediate general drug resistance to many cytotoxic substances also known as pleiotropic drug resistance (PDR). The regulatory mechanisms that activate Pdr1 and Pdr3 in response to the various xenobiotics are poorly understood. In this study, we report that exposure of yeast cells to 2,4-dichlorophenol (DCP), benzyl alcohol, nonionic detergents, and lysophospholipids causes rapid activation of Pdr1 and Pdr3. Furthermore,  ...[more]

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