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Transcription profiling of parotid glands from mice with targeted expression of architectural transcription factor HMGA2

ABSTRACT: Targeted expression of architectural transcription factor HMGA2 in salivary glands of transgenic mice.

ORGANISM(S): Mus musculus

SUBMITTER: David Ann

PROVIDER: E-MEXP-871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice.

Lin H Helen HH Xiong Ye Y Ho Ye-Shih YS Zhou Beiyun B Nguyen Ha-Van HV Deng Hongtao H Lee Renee R Yen Yun Y Borok Zea Z Ann David K DK

European journal of oral sciences 20070201 1

High mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor. Numerous studies have demonstrated that HMGA2 is exclusively expressed in the nucleus of embryonic, but not of terminally differentiated, cells, and aberrant expression of HMGA2 is associated with various benign tumors, including pleomorphic salivary adenoma. Herein, we report the use of a 4.5-kb enhancer/promoter region of the aquaporin-5 (AQP-5) gene to target HMGA2 transgene expression in the mouse sal ...[more]

PMID: 17305714

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