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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rats with colitis induced with trinitrobenzene sulfonate - time series

ABSTRACT: Rats were randomly assigned to one of two different groups, a control (C, n=6) group that received a saline enema and a TNBS group (n=12) that received the TNBS challenge. Food and water intake and body weight were determined daily. To follow the progression of the colitis 3 rats of the TNBS group were killed 2, 5, 7 and 14 days after the induction of colitis. Three control rats were killed on day 2 and the other six at the end (day 14) of the experiment. The rats status was examined by standard techniques and further characterized with microarrays in triplicate (TNBS) or sextuplicate (controls).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Fermin Sanchez de Medina

PROVIDER: E-MEXP-873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis.

Martínez-Augustin Olga O Merlos Manel M Zarzuelo Antonio A Suárez María Dolores MD de Medina Fermín Sánchez FS

BMC genomics 20081017

<h4>Background</h4>Trinitrobenzenesulphonic acid (TNBS) induced rat colitis is one of the most widely used models of inflammatory bowel disease (IBD), a condition whose aetiology and pathophysiology are incompletely understood. We have characterized this model at the genomic level using a longitudinal approach. Six control rats were compared with colitic animals at 2, 5, 7 and 14 days after TNBS administration (n = 3). The Affymetrix Rat Expression Array 230 2.0 system was used.<h4>Results</h4>T ...[more]

PMID: 18928539

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