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RNAi knock down of FAM33A in a human lung carcinoma cell line

ABSTRACT: The effect of endogenous FAM33A knockdown by RNAi on the gene expression profile of a lung carcinoma cell line

ORGANISM(S): Homo sapiens

SUBMITTER: David Ray

PROVIDER: E-MEXP-875 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.

Rice Lisa L Waters Charlotte E CE Eccles Jennifer J Garside Helen H Sommer Paula P Kay Paul P Blackhall Fiona H FH Zeef Leo L Telfer Brian B Stratford Ian I Clarke Rob R Singh Dave D Stevens Adam A White Anne A Ray David W DW

The Journal of endocrinology 20080626 3

Glucocorticoid (GC) receptors (GRs) have profound anti-survival effects on human small cell lung cancer (SCLC). To explore the basis of these effects, protein partners for GRs were sought using a yeast two-hybrid screen. We discovered a novel gene, FAM33A, subsequently identified as a SKA1 partner and involved in mitosis, and so renamed Ska2. We produced an anti-peptide antibody that specifically recognized full-length human SKA2 to measure expression in human cell lines and tissues. There was a ...[more]

PMID: 18583474

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