Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of E. coli biofilm to assess the global gene impact of a natural F conjugative plasmid-carrying E.coli biofilm


ABSTRACT: we examined the three different mature biofilms and searched the genes which promoted the rapid biofilm formation when their population hosing the plasmids. We investigate the global transcriptional differences between the non-conjugative or conjugative plasmid-carrying and plasmid-free strains.

ORGANISM(S): Escherichia coli

SUBMITTER: Thithiwat May 

PROVIDER: E-MEXP-953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes.

May Thithiwat T   Ito Akinobu A   Okabe Satoshi S  

Antimicrobial agents and chemotherapy 20090831 11


Biofilms gain resistance to various antimicrobial agents, and the presence of antibiotic resistance genes is thought to contribute to a biofilm-mediated antibiotic resistance. Here we showed the interplay between the tetracycline resistance efflux pump TetA(C) and the ampicillin resistance gene (bla(TEM-1)) in biofilms of Escherichia coli harboring pBR322 in the presence of the mixture of ampicillin and tetracycline. E. coli in the biofilms could obtain the high-level resistance to ampicillin, t  ...[more]

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