Transcription profiling of human mesenchymal stem cells transfected with adenoviruses carrying the SOX trio or LacZ control to identify target molecules
Ontology highlight
ABSTRACT:
INSTRUMENT(S): BAS-1800 [FUJIFILM]
ORGANISM(S): Homo sapiens
SUBMITTER: Taku Saito
PROVIDER: E-MEXP-960 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes.
Saito Taku T Ikeda Toshiyuki T Nakamura Kozo K Chung Ung-il UI Kawaguchi Hiroshi H
EMBO reports 20070330 5
Transcription factor SOX9 (sex-determining region Y-type high mobility group box 9) and its coactivators SOX5 and SOX6 (the SOX trio) induce early-stage chondrocyte differentiation and suppress its terminal stage. To identify possible targets of the SOX trio, we carried out a microarray analysis and identified S100A1 and S100B as possible target molecules. S100 protein expression was localized in late proliferative and pre-hypertrophic chondrocytes of the mouse growth plate. Overexpression of S1 ...[more]
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