Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MicroRNA profiling of mouse embryonic stem cells during retinoic acid-induced differentiation

ABSTRACT: Changes in microRNA expression profile during retinoic acid-induced differentiation of mouse embryonic stem cells.

INSTRUMENT(S): GenePix 4000B [Axon Instruments]

ORGANISM(S): Mus musculus

SUBMITTER: Yvonne Tay

PROVIDER: E-MEXP-977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.

Tay Yvonne M-S YM Tam Wai-Leong WL Ang Yen-Sin YS Gaughwin Philip M PM Yang Henry H Wang Weijia W Liu Rubing R George Joshy J Ng Huck-Hui HH Perera Ranjan J RJ Lufkin Thomas T Rigoutsos Isidore I Thomson Andrew M AM Lim Bing B

Stem cells (Dayton, Ohio) 20071004 1

Hundreds of microRNAs (miRNAs) are expressed in mammalian cells, where they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation of translation rate. Functional studies to date have demonstrated that several of these miRNAs are important during development. However, the role of miRNAs in the regulation of stem cell growth and differentiation is not well understood. We show herein that microRNA (miR)-134 levels are maximally elevated at day 4 after retinoic ac ...[more]

PMID: 17916804

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Dataset Information

MicroRNA profiling of mouse embryonic stem cells during retinoic acid-induced differentiation

Publications

MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.

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