Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of 5 human parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin

ABSTRACT: Title: Analysis of gene expression changes involved in the development of acquired drug resistance.
Description: In vitro model of drug resistance consisting of 5 parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin. Model used to identify genes involved in the drug resistant phenotype.

ORGANISM(S): Homo sapiens

SUBMITTER: Ana Arance

PROVIDER: E-MIMR-11 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of mouse adipocytes to determine the role of RIP140 in adipocyte differentiation

Project description:Title: Gene Expression analysis of the role of RIP140 in adipocyte differentiation Description: RIPKO cells are mouse embryo fibroblasts (MEF) that were derived from RIP140-knockout mice and have been established as a RIP140 null cell line, while RIPKO-L7 and RIPKO-L16 are RIPKO cells for which the expression of RIP140 has been reintroduced using a lentiviral expression system. Using an established standard cocktail of hormones that includes IBMX, insulin, dexamethasone and a PPAR gamma agonist the cells were differentiated into adipocytes and RNA isolated at day 0 and day 10 after the addition of the cocktail.

2013-01-30 | E-MIMR-42 | biostudies-arrayexpress

Transcription profiling of human lung adenocarcinoma A549 cells treated with vehicle (DMSO) or Etoposide (ETOP, 10 uM ), Benzo(a)pyrene Cryptolepineand 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine for 6 h, 16 h, 24 h, 48 h and 72 h

Project description:Title: Prediction of cell cycle behaviour in response to DNA damage agents via transcriptomic approach Description: Human lung adenocarcinoma A549 cells were treated with vehicle (DMSO) or Etoposide (ETOP, 10 M-BM-5M ), Benzo(a)pyrene (BaP, 25 M-BM-5M ), Cryptolepine ( CLP, 2.5 M-BM-5M) and 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP, 50 M-BM-5M) for 6 h, 16 h, 24 h, 48 h and 72 h.

2006-06-01 | E-MIMR-102 | biostudies-arrayexpress

Transcription profiling of human heart tissue: hibernating versus normal myocardium

Project description:Title: Gene expression profiling of human heart samples: a comparison between normal and hibernating myocardium. Description: The aim of this project is to investigate the changes in global gene expression in hibernating,(preserved wall thickness, impaired contractility at rest, recruitable with low dose dobutamine and 50% transmural hyperenhancement with gadolinium) and normal myocardium, (preserved myocardial wall thickness, normal contractility, no significant improvement in functional recruitability with dobutamine and no cardiac fibrosis seen).

2006-12-31 | E-MIMR-27 | biostudies-arrayexpress

Transcription profiling of rat neonatal ventricular myocytes

Project description:Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes. Description: The aim of this study is to identify the changes in gene expression induced in rat neonatal ventricular myocytes, a well-established cell culture model, by endothelin-1, a known hypertrophic agonist, and to determine which of the changes are mediated through the ERK cascade. This continues TKAC^Ys previous study of the effects of oxidative stress, which induces cardiac myocyte apoptosis.

2006-10-01 | E-MIMR-3 | biostudies-arrayexpress

Transcription profiling of BXSB mice to study lupus erythematosus

Project description:Genetic basis of systemic lupus erythematosus in BXSB mice.

2013-01-30 | E-MIMR-7 | biostudies-arrayexpress

Transcription profiling of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice

Project description:Title: Comparison of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice. Description: RIP140 null mice fail to ovulate. This experiment was designed to determine the gene expression profile of these animals compared to wild type and heterozygous animals following hormone treatments that induce the biological changes required for ovulation to occur.

2005-05-11 | E-MIMR-43 | biostudies-arrayexpress

Transcription profiling of phenylepherine response in rat neonatal ventricular myocytes

Project description:Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes. Description: We aim to identify the changes in gene expression induced in rat neonatal ventricular myocytes, a well established cell culture model, by phenylepherine, a known hypertrophic agonist, and to determine which of the changes are mediated through the ERK cascade. In addition, we intend to extend the previous studies (EXP_TKAC_0102_01 and EXP_TKAC_1103_02) on endothelin-1 induced hypertrophy and the oxidative stress induced by H2O2 by using additional concentrations and timepoints.

2006-10-01 | E-MIMR-37 | biostudies-arrayexpress

Transcription profiling of Medicago truncatula cell suspension cultures treated with invertase and/or S.meliloti lipopolysaccharide

Project description:This experiment studies the effect of different compounds on gene expression in M. truncatula cell cultures.

2006-12-31 | E-MEXP-924 | biostudies-arrayexpress

Transcription profiling of PPAR alpha function in fibrate fed animals during light and dark cycles

Project description:Title: Study of PPAR alpha function in fibrate fed animals during light and dark cycles. Description: Study of PPAR alpha function in fibrate fed animals during light and dark cycles.

2005-05-10 | E-MIMR-2 | biostudies-arrayexpress

Proteomic Analysis of Human Brown Adipose Tissue Reveals Utilization of Coupled and Uncoupled Energy Expenditure Pathways

Project description:Human brown adipose tissue (BAT) has become an attractive target to combat the current epidemical spread of obesity and its associated co-morbidities. Currently, information on its functional role is primarily derived from rodent studies. Here, we present the first comparative proteotype analysis of primary human brown adipose tissue versus adjacent white adipose tissue, which reveals significant quantitative differences in protein abundances and in turn differential functional capabilities. The majority of the 318 proteins with increased abundance in BAT are associated with mitochondrial metabolism and confirm the increased oxidative capacity. In addition to uncoupling protein 1 (UCP1), the main functional effector for uncoupled respiration, we also detected the mitochondrial creatine kinases (CKMT1A/B, CKMT2), as effective modulators of ATP synthase coupled respiration, to be exclusively expressed in BAT. The abundant expression and utilization of both energy expenditure pathways in parallel highlights the complex functional involvement of BAT in human physiology.

2016-07-21 | PXD003843 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data