Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Anna Dominiczak
PROVIDER: E-MIMR-541 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
McBride Martin W MW Carr Fiona J FJ Graham Delyth D Anderson Niall H NH Clark James S JS Lee Wai K WK Charchar Fadi J FJ Brosnan M Julia MJ Dominiczak Anna F AF
Hypertension (Dallas, Tex. : 1979) 20021202 3 Pt 2
Human essential hypertension is a complex polygenic trait with underlying genetic components that remain unknown. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of human essential hypertension, and a number of reproducible blood pressure regulation quantitative trait loci have been found to map to rat chromosome 2. The SP.WKYGla2c* congenic strain was produced by introgressing a region of rat chromosome 2 from the normotensive Wistar Kyoto (WKY) strain into the genetic backgr ...[more]