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Transcription profiling of brains, hindlimbs and tails of Xenopus laevis tadpoles after treatment with thyroid hormone


ABSTRACT: Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpoles (NF54) were treated with 100 nM T3(triioodthyronine) in 0.1 x MMR for another 24h and 48h or without T3 for 48h (control group). NF 61 tadpoles were in 0.1 X MMR till they reached NF stage 62. The tails were dissected after the experiment.

ORGANISM(S): Xenopus laevis

SUBMITTER: Yong Qian 

PROVIDER: E-MNIA-94 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression changes at metamorphosis induced by thyroid hormone in Xenopus laevis tadpoles.

Das Biswajit B   Cai Liquan L   Carter Mark G MG   Piao Yu-Lan YL   Sharov Alexei A AA   Ko Minoru S H MS   Brown Donald D DD  

Developmental biology 20060203 2


Thyroid hormone (TH) controlled gene expression profiles have been studied in the tail, hind limb and brain tissues during TH-induced and spontaneous Xenopus laevis metamorphosis. Amplified cRNA probes mixed with a universal standard were hybridized to a set of 21,807-sense strand 60-mer oligonucleotides on each slide representing the entries in X. laevis UniGene Build 48. Most of the up-regulated genes in hind limb and brain are the same. This reflects in part the fact that the initial response  ...[more]

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