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Comparison of human Inflammatory and non-Inflammatory breast cancer samples

ABSTRACT: In this study we generated gene expression profiles of 41 and 55 samples of patients with and without inflammatory breast cancer (IBC vs. non-IBC). The aim of the study was to delineate the specific transcriptional profile of the samples from patients with IBC in search for diagnostic, prognostic and predictive biomarkers.

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Van Laere

PROVIDER: E-MTAB-1006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype.

Van der Auwera I I Limame R R van Dam P P Vermeulen P B PB Dirix L Y LY Van Laere S J SJ

British journal of cancer 20100727 4

<h4>Background</h4>MicroRNAs (miRNAs) are key regulators of gene expression. In this study, we explored whether altered miRNA expression has a prominent role in defining the inflammatory breast cancer (IBC) phenotype.<h4>Methods</h4>We used quantitative PCR technology to evaluate the expression of 384 miRNAs in 20 IBC and 50 non-IBC samples. To gain understanding on the biological functions deregulated by aberrant miRNA expression, we looked for direct miRNA targets by performing pair-wise corre ...[more]

PMID: 20664596

Publication: 1/5

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