Dataset Information
RNA-seq data of HTR1A antagonist WAY-100635 maleate treated GT1-7 cells against untreated control
Ontology highlight
ABSTRACT:
INSTRUMENT(S): HiSeq X Ten
ORGANISM(S): Mus musculus
SUBMITTER: Yihang Shen
PROVIDER: E-MTAB-10171 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The epigenetic role of HTR1A antagonist in facilitaing GnRH expression for pubertal initiation control.
Molecular therapy. Nucleic acids 20210602
Serotonin (5-hydroxytryptamine [5-HT]), a metabolite of tryptophan, acts on the components of the hypothalamus-hypophysis-gonad axis and induces puberty delay in mammals via 5-HT receptor 1A (HTR1A). However, the roles of HTR1A in the hypothalamus in pubertal regulation of gene expression are not fully understood. In the current study, the upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the HTR1A antagonist WAY-100635 maleate was observed <i>i ...[more]
