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RNA-seq data of HTR1A antagonist WAY-100635 maleate treated GT1-7 cells against untreated control

ABSTRACT: GT1-7 cells were treated with 100 μg/mL HTR1A antagonist WAY-100635 maleate for 6 h and harvested for RNA-seq. This study aimed to investigate the expression of gonadotropin-releasing hormone and the differential expressed genes affected by HTR1A inhibition.

INSTRUMENT(S): HiSeq X Ten

ORGANISM(S): Mus musculus

SUBMITTER: Yihang Shen 

PROVIDER: E-MTAB-10171 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The epigenetic role of HTR1A antagonist in facilitaing GnRH expression for pubertal initiation control.

Zhou Shasha S   Shen Yihang Y   Zang Shaolian S   Yin Xiaoqin X   Li Pin P  

Molecular therapy. Nucleic acids 20210602

Serotonin (5-hydroxytryptamine [5-HT]), a metabolite of tryptophan, acts on the components of the hypothalamus-hypophysis-gonad axis and induces puberty delay in mammals via 5-HT receptor 1A (HTR1A). However, the roles of HTR1A in the hypothalamus in pubertal regulation of gene expression are not fully understood. In the current study, the upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the HTR1A antagonist WAY-100635 maleate was observed <i>i  ...[more]

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