Unknown,Transcriptomics,Genomics,Proteomics

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Promoter capture Hi-C of human SGBS (Simpson-Golabi-Behmel syndrome preadipocyte) cells and iPSC-derived hypothalamic cells


ABSTRACT: To identify distal chromatin contacts between promoters and their putative regulatory elements in SGBS preadipocytes and hypothalamic arcuate-like neurons derived from iPSC, we performed Hi-C with a capture step to enrich the library for contacts involving promoters. Hi-C with a capture step was performed according to PMID: 29988018

ORGANISM(S): Homo sapiens

SUBMITTER: Marcelo Nobrega 

PROVIDER: E-MTAB-10200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Whereas coding variants often have pleiotropic effects across multiple tissues, noncoding variants are thought to mediate their phenotypic effects by specific tissue and temporal regulation of gene expression. Here, we investigated the genetic and functional architecture of a genomic region within the <i>FTO</i> gene that is strongly associated with obesity risk. We show that multiple variants on a common haplotype modify the regulatory properties of several enhancers targeting <i>IRX3</i> and <  ...[more]

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