Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marcelo Nobrega
PROVIDER: E-MTAB-10200 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Science (New York, N.Y.) 20210601 6546
Whereas coding variants often have pleiotropic effects across multiple tissues, noncoding variants are thought to mediate their phenotypic effects by specific tissue and temporal regulation of gene expression. Here, we investigated the genetic and functional architecture of a genomic region within the <i>FTO</i> gene that is strongly associated with obesity risk. We show that multiple variants on a common haplotype modify the regulatory properties of several enhancers targeting <i>IRX3</i> and < ...[more]