Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of human monocytic cell line (THP-1) treated with compound 81 or vehicle controls

ABSTRACT: To explore the effects of compound 81 on RNA transcription of THP-1 cells, we performed RNA-seq analysis.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Tomoko Hayashi 

PROVIDER: E-MTAB-10269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection.

Sato-Kaneko Fumi F   Yao Shiyin S   Lao Fitzgerald S FS   Nan Jason J   Shpigelman Jonathan J   Cheng Annette A   Saito Tetsuya T   Messer Karen K   Pu Minya M   Shukla Nikunj M NM   Cottam Howard B HB   Chan Michael M   Molina Anthony J AJ   Corr Maripat M   Hayashi Tomoko T   Carson Dennis A DA  

Proceedings of the National Academy of Sciences of the United States of America 20210601 23

Vaccine adjuvants enhance and prolong pathogen-specific protective immune responses. Recent reports indicate that host factors-such as aging, pregnancy, and genetic polymorphisms-influence efficacies of vaccines adjuvanted with Toll-like receptor (TLR) or known pattern-recognition receptor (PRR) agonists. Although PRR independent adjuvants (e.g., oil-in-water emulsion and saponin) are emerging, these adjuvants induce some local and systemic reactogenicity. Hence, new TLR and PRR-independent adju  ...[more]

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