Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Single-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation


ABSTRACT: We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates dynamic regulations associated with the menstrual cycle. These inductions show that in vitro downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively.

INSTRUMENT(S): Illumina NovaSeq 6000, Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Louis-Francois Handfield 

PROVIDER: E-MTAB-10283 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2019-10-16 | E-MTAB-8089 | biostudies-arrayexpress
2021-12-01 | E-MTAB-10605 | biostudies-arrayexpress
2023-05-05 | E-MTAB-11283 | biostudies-arrayexpress
2019-10-16 | E-MTAB-8087 | biostudies-arrayexpress
2015-05-07 | E-GEOD-65253 | biostudies-arrayexpress
2019-10-16 | E-MTAB-8083 | biostudies-arrayexpress
2021-07-21 | E-MTAB-10287 | biostudies-arrayexpress
2019-10-16 | E-MTAB-8043 | biostudies-arrayexpress
2019-05-15 | E-MTAB-7660 | biostudies-arrayexpress
2024-02-28 | E-MTAB-13828 | biostudies-arrayexpress