Project description:BXH/HXB rat recombinant inbred (RI) strains are derived from the spontaneously hypertensive rat (SHR/Ola) and the Brown Norway congenic strains carrying the polydactylyl-luxate mutation (BN-Lx). Tissue from the apex of left ventricle of the heart was disected from 128 RI SHR/Ola and BN-Lx parental strains, RNA was extracted and labelled and hybridised to Affymetrix Rat Genome 230 2.0 Arrays.

2008-04-01 | E-MIMR-222 | biostudies-arrayexpress

Transcription profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains

Project description:Gene expression profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains.

2010-11-18 | E-AFMX-7 | biostudies-arrayexpress

Genetic Modulation of Protein Expression in Rat Brain

Project description:Genetic linkage analyses in rodents have unveiled numerous genomic loci contributing to a diverse array of traits, such as susceptibility to addictive behaviors and hypertension. To investigate the genetic basis of trait variation in rodents, genetic reference populations, such as the HXB/BXH recombinant inbred (RI) rat panel, have been extensively utilized. The HXB/BXH panel serves as a well-established rat model to dissect genetic variants that modulate metabolic and cardiovascular diseases. The panel has accumulated a wealth of comprehensive genotypic data, transcriptomic profiles, and phenotypic data, enabling integrative analyses to understand the pathway from genomic loci to traits. The parental strains of the HXB/BXH rat panel, SHR/OlaIpcv (SHR) and BN-Lx/Cub (BN-Lx) strains, have been completely sequenced, and sequence variants between them have been well-defined. Integrating genomics, transcriptomics, and proteomics data from these two inbred strains, have successfully identified splice events, genetic variants, and RNA editing. However, there remains a lack of proteome-wide profiling across all 30 HXB/BXH RI strains, and the genetic regulation of protein expression remains largely unexplored.

2024-12-11 | PXD058748 | Pride

Profiling of copy-number variation between BN and SHR rats

Project description:We used Nimblegen HD aCGH to detect copy-number variants between genomes of BN and SHR rats

2010-01-30 | GSE20102 | GEO