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Transcriptome comparison of active and regressed testes of Microtus duodecimcostatus

ABSTRACT: We also study the changes occurring in the testes of Mediterranean pine mice living in the wastelands during the breeding cycle. The transcriptomic analysis of active and regressed testis show that several molecular pathways that operate in Sertoli cells, involved in the control of spermatogenesis and BTB dynamics, are deregulated in the inactive gonad, and that the immuno privilege of the testes is lost during the non-breeding season.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Microtus duodecimcostatus

SUBMITTER: Miguel Burgos

PROVIDER: E-MTAB-10291 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mediterranean Pine Vole, <i>Microtus duodecimcostatus:</i> A Paradigm of an Opportunistic Breeder.

Lao-Pérez Miguel M Massoud Diaa D Real Francisca M FM Hurtado Alicia A Ortega Esperanza E Burgos Miguel M Jiménez Rafael R Barrionuevo Francisco J FJ

Animals : an open access journal from MDPI 20210601 6

Most mammalian species of the temperate zones of the Earth reproduce seasonally, existing a non-breeding period in which the gonads of both sexes undergo functional regression. It is widely accepted that photoperiod is the principal environmental cue controlling these seasonal changes, although several exceptions have been described in other mammalian species in which breeding depends on cues such as food or water availability. We studied the circannual reproductive cycle in males of the Mediter ...[more]

PMID: 34205873

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