Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib

ABSTRACT: To investigate changes to gene expression associated with resistance to lapatinib, we performed ATAC-seq on OE19 cells treated with 500 nM lapatinib for 1, 7 and 35 days and vehicle control (DMSO) for 1 day.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Sharrocks 

PROVIDER: E-MTAB-10304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma.

Ogden Samuel S   Ahmed Ibrahim I   Yang Shen-Hsi SH   Fullwood Paul P   Francavilla Chiara C   Sharrocks Andrew D AD  

NAR cancer 20230123 1

Oesophageal adenocarcinoma (OAC) is a deadly disease with poor survival statistics and few targeted therapies available. One of the most common molecular aberrations in OAC is amplification or activation of the gene encoding the receptor tyrosine kinase ERBB2, and ERBB2 is targeted in the clinic for this subset of patients. However, the downstream consequences of these ERBB2 activating events are not well understood. Here we used a combination of phosphoproteomics, open chromatin profiling and t  ...[more]

PMID: 36694726

Publication: 1/2

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