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Comparison of gene microarray analysis in CD14+ monocytes between anti-MDA5-positive three patients and three healthy controls

ABSTRACT: mRNA array was conducted to identify relevant pathological pathways in activated monocytes in anti-MDA5-positive patients in comparison of those in healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Takahisa Gono

PROVIDER: E-MTAB-10472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease.

Gono Takahisa T Okazaki Yuka Y Kuwana Masataka M

Rheumatology (Oxford, England) 20220201 2

<h4>Objective</h4>To evaluate upstream and downstream regulators leading to macrophage activation and subsequent cytokine storm in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-associated interstitial lung disease (ILD).<h4>Methods</h4>We conducted an integrated miRNA-mRNA association analysis using circulating monocytes from 3 patients with anti-MDA5-associated ILD and 3 healthy controls and identified disease pathways and a regulator effect network by Ingenuity ...[more]

PMID: 33890985

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