Whole DNA methylome of an extramedullary multiple myeloma patient derived orthotopic xenograft

ABSTRACT: A patient derived orthotopic xenograft (PDOX) was generated from a patient with an 53 aggressive extramedullary multiple myeloma (EMM) to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. Whole DNA methylome of the EMM PDOX was also evaluated and compared with a published dataset of 101 newly-diagnosed and chemotherapy-naïve MM patients and normal plasma cells (NPC) (Agirre et al., 2015) A rather balanced proportion of hyper/hypomethylated sites different to previously reported widespread hypomethylation in MM was observed.

ORGANISM(S): Homo sapiens

SUBMITTER: Lourdes Farre Vallve 

PROVIDER: E-MTAB-10654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress