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Whole DNA methylome of an extramedullary multiple myeloma patient derived orthotopic xenograft

ABSTRACT: A patient derived orthotopic xenograft (PDOX) was generated from a patient with an 53 aggressive extramedullary multiple myeloma (EMM) to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. Whole DNA methylome of the EMM PDOX was also evaluated and compared with a published dataset of 101 newly-diagnosed and chemotherapy-naïve MM patients and normal plasma cells (NPC) (Agirre et al., 2015) A rather balanced proportion of hyper/hypomethylated sites different to previously reported widespread hypomethylation in MM was observed.

ORGANISM(S): Homo sapiens

SUBMITTER: Lourdes Farre Vallve

PROVIDER: E-MTAB-10654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Extramedullary multiple myeloma patient-derived orthotopic xenograft with a highly altered genome: combined molecular and therapeutic studies.

Farre Lourdes L Sanz Gabriela G Ruiz-Xivillé Neus N Castro de Moura Manuel M Martin-Tejera Juan Francisco JF Gonçalves-Ribeiro Samuel S Martinez-Iniesta Maria M Calaf Monica M Luis Mosquera Jose J Martín-Subero José Ignacio JI Granada Isabel I Esteller Manel M Domingo-Domenech Eva E Climent Fina F Villanueva Alberto A Sureda Anna A

Disease models & mechanisms 20210715 7

Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established. Besides, well-characterized preclinical models for EMM are not available. Herein, a patient-derived orthotopic xenograft (PDOX) was generated from a patient with an aggressive EMM to study in-depth genetic and epigenetic events, and drug responses rel ...[more]

PMID: 33988237

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