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Unknown,Transcriptomics,Genomics,Proteomics

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Proteasome regulator PSME4 reduces cellular inflammation and promotes an immunosuppressive tumor microenvironment

ABSTRACT: We observed that proteasome regulator PSME4 inhibits antigen presentation and reduces cellular inflammation in lung adenocarcinoma. As tumor inflammation and antigenicity are key to anti-tumor immunity, we examined the effect of PSME4 in vivo by injecting mice with either KP1.9 or KP1.9PSME4_KD lung adenocarcinoma. We analyzed the changes in the immune milieu by performing single cell RNA sequencing (sc-RNA seq) of CD45+ cells, 3 weeks following injection of tumor cells. This allowed us to examine the effect of PSME4 on the early immune response to the tumor.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Aaron Javitt

PROVIDER: E-MTAB-10745 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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