Transcriptional control of hypoxic hyphal growth in the fungal pathogen Candida albicans
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ABSTRACT: So far, there is no known regulatory circuits that mediate filamentation of the pathogenic yeast Candida albicans exclusively in response to hypoxia. In this study, we performed a quantitative analysis of gene deletion mutants from different collections of protein kinases and transcriptional regulators to identify specific regulator of the hypoxic filamentation. Our work uncovered two transcription factors, Ahr1 and Tye7, that act as prominent regulators of C. albicans filamentation specifically under hypoxia. In summary, we used genome-wide transcriptional profiling and promoter occupancy to characterize both Ahr1 and Tye7 regulons associated with the hypoxic filamentation in C. albicans.
ORGANISM(S): Candida albicans
SUBMITTER: Adnane Sellam
PROVIDER: E-MTAB-10882 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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