Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Mus musculus
SUBMITTER: Giorgio Anselmi
PROVIDER: E-MTAB-10945 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Azzoni Emanuele E Frontera Vincent V Anselmi Giorgio G Rode Christina C James Chela C Deltcheva Elitza M EM Demian Atanasiu S AS Brown John J Barone Cristiana C Patelli Arianna A Harman Joe R JR Nicholls Matthew M Conway Simon J SJ Morrissey Edward E Jacobsen Sten Eirik W SEW Sparrow Duncan B DB Harris Adrian L AL Enver Tariq T de Bruijn Marella F T R MFTR
Cell reports 20211201 11
Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1<sup>-/-</sup> mouse embryos devoid of circulation the HSC lineage develops until the phenotypic pro-HSC stage. However, these cells reside in an abn ...[more]