Ontology highlight
ABSTRACT:
INSTRUMENT(S): HiSeq X Ten
ORGANISM(S): Homo sapiens
SUBMITTER: Claudia Pommerenke
PROVIDER: E-MTAB-11039 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Quentmeier Hilmar H Pommerenke Claudia C Drexler Hans G HG
Current issues in molecular biology 20211130 3
For many years, immortalized tumor cell lines have been used as reliable tools to understand the function of oncogenes and tumor suppressor genes. Today, we know that tumors can comprise subclones with common and with subclone-specific genetic alterations. We sequenced DNA and RNA of sequential sister cell lines obtained from patients with pre-B acute lymphoblastic leukemia at different phases of the disease. All five pairs of cell lines carry alterations that are typical for this disease: loss ...[more]