Single-Cell RNA-seq of bat and human fibroblasts stimulated by dsRNA to trigger antiviral response
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ABSTRACT: Dermal fibroblasts from bat and human, stimulated with dsRNA (poly(I:C)) and controls. Bats can harbor some of the most deadliest viruses to humans while rarely displaying pathogenicity themselves. To study the transcriptional divergence and cell-to-cell variability of their innate immune response - the expression program that is initiated once a pathogen is sensed, we stimulated dermal fibroblast cells from Rousettus aegyptiacus and from human for four hours with dsRNA - a viral RNA mimic that triggers a rapid innate immune response. Subsequently, we profiled the response using scRNA-seq.
INSTRUMENT(S): NextSeq 500
ORGANISM(S): mixed sample
SUBMITTER: Stefan Kaltenbach
PROVIDER: E-MTAB-11056 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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